Activity-based protein profiling (ABPP)

Layer 2 — Chemistryin the chemical-biology subtree

Cravatt 1999 ABPP: serine/cysteine-hydrolase active-site directed reactive probes; chemoproteomic readout via MS/MS; basis of target ID + drug-discovery off-target mapping.

Related concepts

Tree (graph-theoretic)
v = V·S/(Km+S) at S = Km ⇒ v = V/2 (half-saturation anchor)

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