Adjuvant mechanisms (MF59 / AS04 / CpG)

Layer 3 — Biologyin the Vaccinology subtree

Adjuvants enhance vaccine immunogenicity via depot-effect + innate-immune activation. Aluminium salts (alum) — first adjuvant 1926, NLRP3-inflammasome. MF59 squalene-emulsion (Novartis) — TLR-independent. AS04 = MPL+alum (TLR4); AS01 =…