Functional-group substitution preserving key interactions (volume, lipophilicity, H-bonding) while altering metabolism or patent space. Classical: –CH₃ → –CF₃, –COOH → tetrazole, –OH → –NHSO₂CH₃.
Functional-group substitution preserving key interactions (volume, lipophilicity, H-bonding) while altering metabolism or patent space. Classical: –CH₃ → –CF₃, –COOH → tetrazole, –OH → –NHSO₂CH₃.