Black-Leff operational model: E = τ·A/(K_A + A(1+τ)); τ-parameter captures receptor-reserve

Layer 3 — Biologyin the neuropharmacology subtree

Black-Leff operational model — the canonical receptor-theory framework separating affinity (K_A) from efficacy (τ) for agonist characterisation (Black & Leff 1983; Kenakin 2007 review). Setup: an agonist A binds a receptor with…

Related concepts

Power series
Black-Leff: E_max=τ/(τ+1); EC_50=K_A/(τ+1); E(EC_50)=τ/[2(τ+1)]; low-A series E≈τA/K_A

Explore Black-Leff operational model: E = τ·A/(K_A + A(1+τ)); τ-parameter captures receptor-reserve on the interactive knowledge graph →