BLAST Karlin-Altschul: E = K·m·n·exp(−λ·S); local-alignment-score EVT (Gumbel) framework

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BLAST Karlin-Altschul extreme-value framework — the canonical local-alignment significance theory underlying BLAST (Altschul, Gish, Miller, Myers & Lipman 1990) and its relatives FASTA, HMMER, DIAMOND. Physical setup: compare a query…

Related concepts

Extreme value theorem
BLAST: E=K·m·n·exp(−λS); doubling n doubles E; S'=(λS−lnK)/ln2; anchor K=0.1,m=1000,n=10⁶,λ=1,S=20

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