Buchwald-Hartwig amination

Layer 2 — Chemistryin the named-reactions subtree

Pd-catalyzed aryl halide + amine → aryl amine. Bulky phosphines (XPhos, RuPhos) enable room-T coupling of unactivated aryl chlorides + anilines + aliphatic amines.

Related concepts

Pd-catalyzed cross-coupling

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