C9orf72 GGGGCC repeat (ALS/FTD)

Layer 3 — Biologyin the Neurodegenerative Disease subtree

DeJesus-Hernandez 2011 / Renton 2011: hexanucleotide repeat expansion (>30 copies) in C9orf72 most common genetic cause of familial ALS + FTD; produces RNA-foci + dipeptide-repeat proteins (poly-GA / poly-GP).

Related concepts

Matrix and determinant
Watson-Crick base pairing

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