Time-of-day dependence of drug efficacy and toxicity. Examples: statins more effective evening (HMG-CoA peaks at night), chemotherapy tolerance varies ±50% with dosing time, morning glucocorticoid dosing matches cortisol rhythm.
Time-of-day dependence of drug efficacy and toxicity. Examples: statins more effective evening (HMG-CoA peaks at night), chemotherapy tolerance varies ±50% with dosing time, morning glucocorticoid dosing matches cortisol rhythm.