Transcription–translation feedback loop: CLOCK:BMAL1 heterodimer drives expression of Per, Cry; PER:CRY complexes feed back to inhibit CLOCK:BMAL1. Delayed negative feedback generates ~24 h oscillations. Conserved from Drosophila (per,…
Transcription–translation feedback loop: CLOCK:BMAL1 heterodimer drives expression of Per, Cry; PER:CRY complexes feed back to inhibit CLOCK:BMAL1. Delayed negative feedback generates ~24 h oscillations. Conserved from Drosophila (per,…