Clonal dynamics neutral drift

Layer 3 — Biologyin the Stem Cells And Development Principles subtree

Klein-Simons (2011) stem-cell-niche model: equipotent stem cells follow neutral Markov birth-death with stochastic loss/replacement; clone-size distribution P(n,t) shows scaling n/√t and exponential tail. Lineage-tracing data (gut,…

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