Nowell 1976: tumors progress through repeated rounds of somatic mutation and clonal selection acting on heritable variation in malignant cell populations. Modern view (Greaves-Maley branched evolution) emphasizes non-linear trajectories:…
Nowell 1976: tumors progress through repeated rounds of somatic mutation and clonal selection acting on heritable variation in malignant cell populations. Modern view (Greaves-Maley branched evolution) emphasizes non-linear trajectories:…