Binding of one substrate (or ligand) molecule alters the affinity of remaining sites. Positive cooperativity (n_H > 1) produces sigmoidal binding curves — hemoglobin/O₂, ATCase, PFK. Negative cooperativity (n_H < 1) smooths the response —…
Binding of one substrate (or ligand) molecule alters the affinity of remaining sites. Positive cooperativity (n_H > 1) produces sigmoidal binding curves — hemoglobin/O₂, ATCase, PFK. Negative cooperativity (n_H < 1) smooths the response —…