~500-2000 bp region with elevated CpG frequency (>50%) and lower methylation, commonly at promoters of ~70% of mammalian genes. Aberrant hypermethylation silences tumor suppressors in cancer.
~500-2000 bp region with elevated CpG frequency (>50%) and lower methylation, commonly at promoters of ~70% of mammalian genes. Aberrant hypermethylation silences tumor suppressors in cancer.