CRISPR-Cas9 (Charpentier-Doudna 2012)

Layer 2 — Chemistryin the bioorganic-chemistry subtree

Jinek-Charpentier-Doudna 2012 (Nobel 2020) RNA-guided endonuclease Cas9; modular DNA targeting; revolutionized genome editing; therapeutic Casgevy 2023 sickle-cell.

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Tree (graph-theoretic)

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