CRISPR NHEJ indel yield: p_cut=1−e^{−μt}; Poisson-process per-cell-cycle cut-rate framework

Layer 3 — Biologyin the biotechnology subtree

CRISPR NHEJ indel-yield Poisson framework — the canonical stochastic model for Cas9-mediated gene editing efficiency at a target locus per cell cycle (Doench et al. 2016; Zhang lab genome-wide screens; Shou et al. 2018). Setup: a…

Related concepts

Poisson process
CRISPR indel: p_cut=1−e^{−μt}; t_half=log(2)/μ; at μt=1: p_cut=1−1/e; at μt=ln2: p_cut=1/2

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