Cryo-EM Bayesian 3D reconstruction (RELION)

Layer 3 — Biologyin the Structural Biology Methods subtree

Scheres 2012 RELION: maximum-a-posteriori reconstruction θ* = argmax p(X|θ)p(θ) on volume θ given particle images X; Wiener-filter regularisation by prior p(θ). EM algorithm alternates orientation marginalisation (E) and volume update…

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