Ser/Thr kinase active only when bound to cognate cyclin + T-loop phosphorylated + CKI-unbound. CDK1 (MPF, mitosis), CDK2 (S-phase), CDK4/6 (G1). Drug target (palbociclib, ribociclib).
Ser/Thr kinase active only when bound to cognate cyclin + T-loop phosphorylated + CKI-unbound. CDK1 (MPF, mitosis), CDK2 (S-phase), CDK4/6 (G1). Drug target (palbociclib, ribociclib).