Cytokine signaling (JAK-STAT)

Layer 3 — Biologyin the Immunology subtree

Darnell-Stark-Kerr 1990s JAK-STAT: cytokine-receptor dimerization recruits JAK1/2/3/TYK2 -> phospho-STAT1-6 -> nuclear-translocation -> gene-induction; basis of IFN/IL-6 signaling.

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