De-novo pyrimidine biosynthesis

Layer 3 — Biologyin the Amino Acid And Nucleotide Metabolism subtree

Six-step biosynthesis of UMP from carbamoyl-P + aspartate (via CAD complex + DHODH + UMPS). UMP → UTP → CTP; dUMP → dTMP by thymidylate synthase (target of 5-FU).

Related concepts

Cytosine (C)
Thymine (T)
Uracil (U)

Explore De-novo pyrimidine biosynthesis on the interactive knowledge graph →