CpG dinucleotides are mostly methylated (5-methylcytosine) in mammalian genomes; CpG islands (~70% of gene promoters) are unmethylated. Hypermethylation of CpG-island promoters silences tumour-suppressor genes (MLH1, BRCA1) in cancer. …
CpG dinucleotides are mostly methylated (5-methylcytosine) in mammalian genomes; CpG islands (~70% of gene promoters) are unmethylated. Hypermethylation of CpG-island promoters silences tumour-suppressor genes (MLH1, BRCA1) in cancer. …