ED50, LD50, therapeutic index

Layer 3 — Biologyin the Pharmacology subtree

ED50: dose producing half-maximal effect in half the population. LD50: dose killing half. Therapeutic index TI = LD50/ED50 — higher is safer. Narrow-TI drugs (digoxin, warfarin) need monitoring.

Related concepts

Dose-response curve
Therapeutic drug monitoring

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