Clark 1933 / Hill-Langmuir: drug effect E = E_max [D]^n / (EC_50^n + [D]^n) follows from receptor occupancy at equilibrium. Operational model (Black-Leff 1983) extends to partial agonists via efficacy parameter τ; basis of all…
Clark 1933 / Hill-Langmuir: drug effect E = E_max [D]^n / (EC_50^n + [D]^n) follows from receptor occupancy at equilibrium. Operational model (Black-Leff 1983) extends to partial agonists via efficacy parameter τ; basis of all…