Erythropoietin (EPO) + hypoxia sensing

Layer 3 — Biologyin the hematology subtree

Goldwasser 1977 / Semenza 1992 HIF-1: kidney peritubular cells sense O2 via HIF-stabilization; secrete EPO -> bone marrow RBC production; basis of altitude-acclimation + EPO-doping.

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