FMO regioselectivity framework: pyrrole C-2 vs C-3 electrophilic attack 2:1 resonance ratio

Layer 2 — Chemistryin the heterocyclic-chemistry subtree

The frontier-molecular-orbital (FMO) regio-selectivity framework for electrophilic aromatic substitution (SEAr) on 5-ring π-excessive heteroaromatics (pyrrole, furan, thiophene). Physical origin: π-excessive heterocycles have 6…

Related concepts

Aromaticity (Hückel rule)
Pyrrole SEAr: N_{C2}/N_{C3} = 2 (resonance count); f_{C2} = 2/3 (statistical fraction)
Dual space V*

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