GPCR signaling (Lefkowitz-Kobilka)

Layer 3 — Biologyin the Cell Signaling subtree

Lefkowitz-Kobilka Nobel 2012: GPCRs 7TM heterotrimeric Galphabetagamma activation -> beta-arrestin desensitization; ~30% of FDA drugs target GPCRs; classes A/B/C/F.

Related concepts

Ordinary differential equation (ODE)
Michaelis-Menten kinetics

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