Knudson 1971 + Weinberg 1990s Rb tumor-suppressor: hypophosphorylated Rb binds E2F; cyclinD-CDK4/6 phosphorylates Rb -> E2F released -> S-phase gene transcription.
Knudson 1971 + Weinberg 1990s Rb tumor-suppressor: hypophosphorylated Rb binds E2F; cyclinD-CDK4/6 phosphorylates Rb -> E2F released -> S-phase gene transcription.