Gene expression noise decomposition (Elowitz-Swain)

Elowitz-Levine-Siggia-Swain 2002: 'intrinsic' vs 'extrinsic' noise decomposed via two-color (CFP+YFP) reporter strain — variance(CFP-YFP)/2 = intrinsic (gene-specific stochasticity); covariance = extrinsic (cell-state fluctuations). …