Reconstruction of a genome from sequencing reads. De novo (no reference) via OLC or de Bruijn graph; reference-based (mapping). Challenges: repeats, heterozygosity. Tools: SPAdes, Flye, hifiasm.
Reconstruction of a genome from sequencing reads. De novo (no reference) via OLC or de Bruijn graph; reference-based (mapping). Challenges: repeats, heterozygosity. Tools: SPAdes, Flye, hifiasm.