Parent-of-origin-specific silencing via differentially methylated regions (DMRs) set in the germline. ~100 imprinted loci in mammals; disruption → Angelman, Prader-Willi, Beckwith-Wiedemann syndromes.
Parent-of-origin-specific silencing via differentially methylated regions (DMRs) set in the germline. ~100 imprinted loci in mammals; disruption → Angelman, Prader-Willi, Beckwith-Wiedemann syndromes.