Hallmark: activating invasion and metastasis

Layer 3 — Biologyin the Cancer Biology subtree

Acquisition of migratory and tissue-remodeling capabilities. Steps: loss of E-cadherin (CDH1) releases epithelial adhesion; matrix metalloproteinases (MMP2, MMP9, MT1-MMP) degrade basement membrane; integrin repertoire switch enables…

Related concepts

Hallmarks of cancer (2022 revision)
Metastasis
Anoikis
Metastatic cascade
Epithelial-mesenchymal transition (EMT)

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