Hallmark: resisting cell death

Layer 3 — Biologyin the Cancer Biology subtree

Cancer cells evade apoptotic, necroptotic, and ferroptotic execution. Mechanisms: BCL2-family imbalance (BCL2/BCL-xL/MCL-1 overexpression relative to BAX/BAK/BH3-only); loss of extrinsic-pathway components (FADD, caspase-8); disabled…

Related concepts

Hallmarks of cancer (2022 revision)
Apoptosis
Anoikis
Autophagy

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