HSAB principle (Pearson)

Layer 2 — Chemistryin the periodic-table subtree

Hard acids (Li+, Al³⁺, H+) prefer hard bases (F⁻, O²⁻); soft acids (Hg²⁺, Au+, Pt²⁺) prefer soft bases (I⁻, R₂S, PR₃). Rationalizes complex formation + solubility.

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