Henderson-Hasselbalch equation (Henderson 1908, Hasselbalch 1917): logarithmic rearrangement of the weak-acid equilibrium K_a = [A⁻][H⁺]/[HA]. Taking −log₁₀ of both sides and rearranging: pH = pK_a + log([A⁻]/[HA]). At equimolar…
pH = pKa + log₁₀([A⁻]/[HA]); pI = ½(pKa1 + pKa2) for amino acid
Related concepts
- Acid dissociation constant (Kₐ)
- pH scale
- Brønsted-Lowry acid-base
- pI = ½(pKa1 + pKa2); glycine (2.34, 9.60) ⇒ pI = 5.97
- e (Euler's number)
- Induced-fit (Koshland 1958)
- Self-splicing ribozyme (Cech 1981)
- RNA world (Gilbert 1986)
- Click chemistry (Sharpless 2001)
- Fab fragment (Porter 1959)
- DNA polymerase (Kornberg 1957)
- Lock-and-key (Fischer 1894)
- Ro5 (Lipinski 1997)
- Hammett σρ (1937)
- Free-Wilson QSAR (1964)
- AlphaFold-drug (2022)
- ADMET (van de Waterbeemd 2001)
- Debye-Hückel (1923)
- Born solvation (1920)
- Kirkwood-Onsager dipole