Hill equation: E = E_max·C^n/(EC_50^n + C^n); cooperative-binding sigmoid (1910)

Layer 3 — Biologyin the neuropharmacology subtree

Hill equation framework — the canonical sigmoidal dose-response / cooperative-binding model spanning all of quantitative pharmacology (Hill 1910; Weiss 1997 review; Goutelle 2008 clinical review). Setup: an agonist (or inhibitor) at…

Related concepts

Intermediate value theorem
Hill equation: E(EC_50)=E_max/2; E/(E_max−E)=(C/EC_50)^n; C_x=EC_50·(x/(1−x))^{1/n}

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