Karlin-Altschul BLAST significance statistics

Layer 3 — Biologyin the Omics And Bioinformatics subtree

Karlin-Altschul 1990: number of HSPs with score ≥ S follows Poisson with mean E = K m n e^{-λS}; λ and K depend only on substitution matrix and background frequencies (extreme-value distribution). Yields E-value sensitivity used by every…

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