LOD-score linkage-mapping framework

Layer 3 — Biologyin the Classical And Molecular Genetics subtree

Morton 1955 logarithm-of-odds: LOD = log₁₀[L(θ)/L(0.5)] where L(θ) is the likelihood of recombination fraction θ between two loci. LOD ≥ 3 (1000:1 odds) is conventional threshold for genetic linkage; LOD ≤ -2 excludes linkage. …

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