Mechanotransduction & stem-cell fate (Engler-Discher)

Engler-Discher 2006: substrate stiffness directs MSC differentiation via integrin-FAK-RhoA-YAP/TAZ signalling. Soft (1 kPa) → neuronal; intermediate (10 kPa) → myogenic; stiff (100 kPa) → osteogenic. YAP/TAZ cytoplasmic-vs-nuclear…