MHC restriction (Zinkernagel-Doherty 1974)

Layer 3 — Biologyin the Immunology subtree

Zinkernagel-Doherty 1974 (Nobel 1996): T-cell only recognizes antigen presented in self-MHC context; class-I (CD8) + class-II (CD4) bifurcation; thymic positive/negative selection.

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