Symmetric oligomeric enzyme exists in an equilibrium between an all-T (tense, low affinity) and all-R (relaxed, high affinity) state. Substrate preferentially binds R, shifting the T ⇌ R equilibrium toward R; produces sigmoidal binding…
Symmetric oligomeric enzyme exists in an equilibrium between an all-T (tense, low affinity) and all-R (relaxed, high affinity) state. Substrate preferentially binds R, shifting the T ⇌ R equilibrium toward R; produces sigmoidal binding…