Juxtacrine signalling: Delta/Jagged ligand on neighbour cell activates Notch receptor by triggering S2 (ADAM) + S3 (γ-secretase) cleavages. NICD translocates to nucleus, partners with CSL/MAML. Cell-fate decisions, lateral inhibition.
Juxtacrine signalling: Delta/Jagged ligand on neighbour cell activates Notch receptor by triggering S2 (ADAM) + S3 (γ-secretase) cleavages. NICD translocates to nucleus, partners with CSL/MAML. Cell-fate decisions, lateral inhibition.