Ras / Myc / Bcr-Abl gain-of-function oncogenes; Rb / p53 / APC loss-of-function tumor-suppressors; Knudson 1971 two-hit hypothesis; foundation of molecular oncology.
Ras / Myc / Bcr-Abl gain-of-function oncogenes; Rb / p53 / APC loss-of-function tumor-suppressors; Knudson 1971 two-hit hypothesis; foundation of molecular oncology.