Physiologically-based PK: organism partitioned into compartments (liver, kidney, fat, muscle, ...) with blood-flow-limited or membrane-limited dC/dt = Q_i (C_a - C_i/P_i). Mechanistic; allows interspecies scaling and first-in-human dose…
Physiologically-based PK: organism partitioned into compartments (liver, kidney, fat, muscle, ...) with blood-flow-limited or membrane-limited dC/dt = Q_i (C_a - C_i/P_i). Mechanistic; allows interspecies scaling and first-in-human dose…