PI3K-Akt-mTOR (survival pathway)

Layer 3 — Biologyin the Cell Signaling subtree

Cantley 1988 PI3K + mTOR (Schreiber 1991 / Sabatini 2002): phosphatidyl-inositol 3-kinase generates PIP3; Akt activation; mTORC1/2 control protein-synthesis + autophagy; TSC + rapamycin.

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