Polyketide biogenesis: acetate C₂ head-to-tail via PKS; C1/C2 parity

Layer 2 — Chemistryin the natural-product-chemistry subtree

Polyketide biogenesis (Birch 1953, Staunton & Weissman 2001). Polyketide synthases (PKS) catalyse the iterative condensation of acetyl-CoA (C₂) units via Claisen-like reactions: the α-carbon (C2-methyl) of one acetate attacks the…

Related concepts

Shikimate pathway
Polyketide n=5 parity: C1-count = C2-count = 5; Σ (-1)^(k+1) = 0

Explore Polyketide biogenesis: acetate C₂ head-to-tail via PKS; C1/C2 parity on the interactive knowledge graph →