PROTAC degraders (Crews 2001)

Layer 2 — Chemistryin the chemical-biology subtree

Crews 2001 + Arvinas 2013 PROTAC: bivalent ligand recruits E3-ligase to target -> ubiquitin -> proteasome; ARV-471 estrogen-receptor degrader Phase 3 2024; event-driven pharmacology.

Related concepts

Tree (graph-theoretic)
v = V·S/(Km+S) at S = Km ⇒ v = V/2 (half-saturation anchor)

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