Kinetic+thermodynamic process by which a polypeptide reaches its native fold. Levinthal's paradox resolved by funnel-shaped energy landscapes (Wolynes/Onuchic).
Protein folding
Related concepts
- Tertiary structure
- Hydrophobic effect
- Anfinsen's dogma
- Molecular chaperone
- Intrinsically disordered protein
- X-ray crystallography
- Cryo-electron microscopy
- Protein NMR spectroscopy
- AlphaFold
- Biomolecular molecular dynamics
- Protein aggregation disease
- Single-molecule FRET
- Antifreeze glycoprotein (fish)
- Insect antifreeze protein
- LEA proteins (late-embryogenesis-abundant)
- Tardigrade cryptobiosis
- Cryo-EM vitrification (Dubochet)
- Ice-recrystallisation inhibition (IRI)
- Wilkins proteome term (1995)
- O'Farrell 2D-PAGE