Protein folding

Layer 3 — Biologyin the Protein Structure subtree

Kinetic+thermodynamic process by which a polypeptide reaches its native fold. Levinthal's paradox resolved by funnel-shaped energy landscapes (Wolynes/Onuchic).

Related concepts

Tertiary structure
Hydrophobic effect
Anfinsen's dogma
Molecular chaperone
Intrinsically disordered protein
X-ray crystallography
Cryo-electron microscopy
Protein NMR spectroscopy
AlphaFold
Biomolecular molecular dynamics
Protein aggregation disease
Single-molecule FRET

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