Crews-Deshaies 2001 PROTAC: heterobifunctional small-molecule recruits E3-ubiquitin-ligase to target-protein → ubiquitination + degradation. Catalytic-event-driven (sub-stoichiometric potency). ARV-110 prostate cancer / ARV-471 breast…
Crews-Deshaies 2001 PROTAC: heterobifunctional small-molecule recruits E3-ubiquitin-ligase to target-protein → ubiquitination + degradation. Catalytic-event-driven (sub-stoichiometric potency). ARV-110 prostate cancer / ARV-471 breast…