Schild regression: log(r−1) = log[B] − log K_B; slope = 1 defines competitive antagonism (pA_2)

Layer 3 — Biologyin the neuropharmacology subtree

Schild regression framework — the canonical competitive-antagonism quantification method in pharmacology (Schild 1947, 1949; Arunlakshana & Schild 1959). Setup: an agonist's EC_50 in the presence of antagonist [B] vs without antagonist…

Related concepts

Maximum-likelihood estimation
Schild: log(r−1) canonical log(B/K_B); r(B=K_B)=2, r(B=3K_B)=4, r(B=7K_B)=8; slope/log[B]=1

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