Seebach umpolung cancellation: a1 (natural +1) + d1 (dithiane −1) = 0 (polarity sum invariant)

Layer 2 — Chemistryin the retrosynthesis-strategy subtree

Polarity arithmetic: natural carbonyl C = a1 (+1); dithiane C = d1 (−1); sum = 0. Canonical pins: three exact integers.

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