Surveillance mechanism delaying anaphase until every kinetochore is bi-oriented. Unattached kinetochores produce MCC (Mad2, BubR1, Bub3) that inhibits APC/C-Cdc20 and thus securin destruction.
Surveillance mechanism delaying anaphase until every kinetochore is bi-oriented. Unattached kinetochores produce MCC (Mad2, BubR1, Bub3) that inhibits APC/C-Cdc20 and thus securin destruction.